A New Member of the Ptaon Nucleic Acids Research Ia Protease Inhibitor Gene Family
نویسنده
چکیده
A 2.1-kb cDNA clone representing a new member of the protease inhibitor family was isolated from a human liver cDNA library. The inhibitor, named human Leuserpin 2 (hLS2), comprises 480 ami no acids and contains a leucine residue at its putative reactive center. HLS2 is about 2 5-28% homologous to three huaan members of the plasma protease inhibitor family: antithrombin III, o^l-antitrypsin and c<i-antichymotrypsin. A comparison with published partial amino acid sequences shows that hLS2 is closely related to the thrombin inhibitor heparin cofactor I
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تاریخ انتشار 2005